George Ploubidis , UCL Centre for Longitudinal Studies
David Batty, University College London
David Bann, University College London
Praveetha Patalay, UCL Centre for Longitudinal Studies
Alissa Goodman, UCL Centre for Longitudinal Studies
We investigated the association between trajectories of early life mental health with biomarkers in mid-life and premature all-cause mortality. We used the 1958 British birth cohort which includes prospective data on early life mental health (age 7 to 16), biomarkers at age 44/45 (n = 9210) and information on all – cause mortality up to age 58 (n = 17657). Latent profile analysis was used to derive a longitudinal typology of early life mental health. Linear and log binomial regressions and the Cox proportional hazards model were employed to investigate associations with biomarkers in mid-life and all-cause mortality by age 58. Early life mental health is associated with less favourable levels of biomarkers 29 years later and elevated risk of premature mortality. The associations with biomarkers in mid-life were more commonly seen in females.
Presented in Session 11. Demographic and Health Outcomes of Early Life Exposures